PoplarV1, Main, Exploration, bibRecord, 000A26

Dihydrochalcone Derivatives from Populus balsamifera L. Buds for the Treatment of Psoriasis.

Identifieur interne : 000A26 ( Main/Exploration ); précédent : 000A25; suivant : 000A27

Dihydrochalcone Derivatives from Populus balsamifera L. Buds for the Treatment of Psoriasis.

Auteurs : Audrey Bélanger [Canada] ; Alexe Grenier [Canada] ; François Simard [Canada] ; Isabelle Gendreau [Canada] ; André Pichette [Canada] ; Jean Legault [Canada] ; Roxane Pouliot [Canada]

Source :

International journal of molecular sciences [ 1422-0067 ] ; 2019.

RBID : pubmed:31905943

Descripteurs français

KwdFr :
- Administration par voie topique (MeSH), Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Anti-inflammatoires (usage thérapeutique), Antigène KI-67 (métabolisme), Antioxydants (usage thérapeutique), Chalcones (composition chimique), Chalcones (pharmacologie), Chalcones (usage thérapeutique), Concentration inhibitrice 50 (MeSH), Femelle (MeSH), Humains (MeSH), Ingénierie tissulaire (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Méthotrexate (usage thérapeutique), Peau (anatomopathologie), Populus (composition chimique), Produits dermatologiques (pharmacologie), Produits dermatologiques (usage thérapeutique), Protéines membranaires (métabolisme), Précurseurs de protéines (métabolisme), Psoriasis (anatomopathologie), Psoriasis (traitement médicamenteux), Qualité de vie (MeSH), Épiderme (anatomopathologie), Épiderme (effets des médicaments et des substances chimiques).
MESH :
- anatomopathologie : Peau, Psoriasis, Épiderme.
- composition chimique : Chalcones, Populus.
- effets des médicaments et des substances chimiques : Épiderme.
- métabolisme : Antigène KI-67, Protéines membranaires, Précurseurs de protéines.
- pharmacologie : Chalcones, Produits dermatologiques.
- traitement médicamenteux : Psoriasis.
- usage thérapeutique : Anti-inflammatoires, Antioxydants, Chalcones, Méthotrexate, Produits dermatologiques.
- Administration par voie topique, Adolescent, Adulte, Adulte d'âge moyen, Concentration inhibitrice 50, Femelle, Humains, Ingénierie tissulaire, Jeune adulte, Mâle, Qualité de vie.

English descriptors

KwdEn :
- Administration, Topical (MeSH), Adolescent (MeSH), Adult (MeSH), Anti-Inflammatory Agents (therapeutic use), Antioxidants (therapeutic use), Chalcones (chemistry), Chalcones (pharmacology), Chalcones (therapeutic use), Dermatologic Agents (pharmacology), Dermatologic Agents (therapeutic use), Epidermis (drug effects), Epidermis (pathology), Female (MeSH), Humans (MeSH), Inhibitory Concentration 50 (MeSH), Ki-67 Antigen (metabolism), Male (MeSH), Membrane Proteins (metabolism), Methotrexate (therapeutic use), Middle Aged (MeSH), Populus (chemistry), Protein Precursors (metabolism), Psoriasis (drug therapy), Psoriasis (pathology), Quality of Life (MeSH), Skin (pathology), Tissue Engineering (MeSH), Young Adult (MeSH).
MESH :
- chemical , chemistry : Chalcones.
- chemical , metabolism : Ki-67 Antigen, Membrane Proteins, Protein Precursors.
- chemical , pharmacology : Chalcones, Dermatologic Agents.
- chemical , therapeutic use : Anti-Inflammatory Agents, Antioxidants, Chalcones, Dermatologic Agents, Methotrexate.
- chemistry : Populus.
- drug effects : Epidermis.
- drug therapy : Psoriasis.
- pathology : Epidermis, Psoriasis, Skin.
- Administration, Topical, Adolescent, Adult, Female, Humans, Inhibitory Concentration 50, Male, Middle Aged, Quality of Life, Tissue Engineering, Young Adult.

Abstract

Psoriasis is a skin disorder characterized by epidermal hyperplasia, hyperkeratosis, and inflammation. The treatments currently available on the market only improve patients' quality of life and are associated with undesirable side effects. Thus, research leading to the development of new, effective, and safer therapeutic agents is still relevant. Populus balsamifera L. buds were used traditionally by Native Americans to treat various skin pathologies such as eczema and psoriasis. In this study, the antipsoriatic activities of dihydrochalcone derivatives from Populus balsamifera L. buds, known as balsacones, were investigated. The experiments were performed in vitro using a psoriatic skin substitute model. Also, anti-inflammatory and antioxidant activities were investigated. The tested balsacones showed promising antipsoriatic properties by slowing down cell growth and by regulating the expression of involucrin, loricrin, and Ki67 better than methotrexate in psoriatic substitutes. All five tested compounds could be an effective topical treatment for psoriasis, with promising anti-inflammatory and antioxidant actions that may contribute to clinical improvement in patients with psoriasis.

DOI: 10.3390/ijms21010256
PubMed: 31905943
PubMed Central: PMC6981943

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000531
to stream Main, to step Curation: 000531

Le document en format XML

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 L. Buds for the Treatment of Psoriasis.</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Dihydrochalcone Derivatives from <i>Populus balsamifera</i>
 L. Buds for the Treatment of Psoriasis.</title>
<author><name sortKey="Belanger, Audrey" sort="Belanger, Audrey" uniqKey="Belanger A" first="Audrey" last="Bélanger">Audrey Bélanger</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC GIJ 1Z4, Canada.</nlm:affiliation>
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<country xml:lang="fr">Canada</country>
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<country xml:lang="fr">Canada</country>
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<author><name sortKey="Grenier, Alexe" sort="Grenier, Alexe" uniqKey="Grenier A" first="Alexe" last="Grenier">Alexe Grenier</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculté de Pharmacie, Université Laval, Québec, QC G1V 0A6</wicri:regionArea>
<orgName type="university">Université Laval</orgName>
<placeName><settlement type="city">Québec (ville)</settlement>
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<author><name sortKey="Simard, Francois" sort="Simard, Francois" uniqKey="Simard F" first="François" last="Simard">François Simard</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC G7H 2B1, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC G7H 2B1</wicri:regionArea>
<wicri:noRegion>QC G7H 2B1</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gendreau, Isabelle" sort="Gendreau, Isabelle" uniqKey="Gendreau I" first="Isabelle" last="Gendreau">Isabelle Gendreau</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC GIJ 1Z4, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC GIJ 1Z4</wicri:regionArea>
<wicri:noRegion>QC GIJ 1Z4</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Faculté de Pharmacie, Université Laval, Québec, QC G1V 0A6, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Faculté de Pharmacie, Université Laval, Québec, QC G1V 0A6</wicri:regionArea>
<orgName type="university">Université Laval</orgName>
<placeName><settlement type="city">Québec (ville)</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pichette, Andre" sort="Pichette, Andre" uniqKey="Pichette A" first="André" last="Pichette">André Pichette</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC G7H 2B1, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC G7H 2B1</wicri:regionArea>
<wicri:noRegion>QC G7H 2B1</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Legault, Jean" sort="Legault, Jean" uniqKey="Legault J" first="Jean" last="Legault">Jean Legault</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC G7H 2B1, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC G7H 2B1</wicri:regionArea>
<wicri:noRegion>QC G7H 2B1</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pouliot, Roxane" sort="Pouliot, Roxane" uniqKey="Pouliot R" first="Roxane" last="Pouliot">Roxane Pouliot</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC GIJ 1Z4, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC GIJ 1Z4</wicri:regionArea>
<wicri:noRegion>QC GIJ 1Z4</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Faculté de Pharmacie, Université Laval, Québec, QC G1V 0A6, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
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<series><title level="j">International journal of molecular sciences</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Topical (MeSH)</term>
<term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Anti-Inflammatory Agents (therapeutic use)</term>
<term>Antioxidants (therapeutic use)</term>
<term>Chalcones (chemistry)</term>
<term>Chalcones (pharmacology)</term>
<term>Chalcones (therapeutic use)</term>
<term>Dermatologic Agents (pharmacology)</term>
<term>Dermatologic Agents (therapeutic use)</term>
<term>Epidermis (drug effects)</term>
<term>Epidermis (pathology)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Inhibitory Concentration 50 (MeSH)</term>
<term>Ki-67 Antigen (metabolism)</term>
<term>Male (MeSH)</term>
<term>Membrane Proteins (metabolism)</term>
<term>Methotrexate (therapeutic use)</term>
<term>Middle Aged (MeSH)</term>
<term>Populus (chemistry)</term>
<term>Protein Precursors (metabolism)</term>
<term>Psoriasis (drug therapy)</term>
<term>Psoriasis (pathology)</term>
<term>Quality of Life (MeSH)</term>
<term>Skin (pathology)</term>
<term>Tissue Engineering (MeSH)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie topique (MeSH)</term>
<term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Anti-inflammatoires (usage thérapeutique)</term>
<term>Antigène KI-67 (métabolisme)</term>
<term>Antioxydants (usage thérapeutique)</term>
<term>Chalcones (composition chimique)</term>
<term>Chalcones (pharmacologie)</term>
<term>Chalcones (usage thérapeutique)</term>
<term>Concentration inhibitrice 50 (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Ingénierie tissulaire (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Méthotrexate (usage thérapeutique)</term>
<term>Peau (anatomopathologie)</term>
<term>Populus (composition chimique)</term>
<term>Produits dermatologiques (pharmacologie)</term>
<term>Produits dermatologiques (usage thérapeutique)</term>
<term>Protéines membranaires (métabolisme)</term>
<term>Précurseurs de protéines (métabolisme)</term>
<term>Psoriasis (anatomopathologie)</term>
<term>Psoriasis (traitement médicamenteux)</term>
<term>Qualité de vie (MeSH)</term>
<term>Épiderme (anatomopathologie)</term>
<term>Épiderme (effets des médicaments et des substances chimiques)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Chalcones</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Ki-67 Antigen</term>
<term>Membrane Proteins</term>
<term>Protein Precursors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Chalcones</term>
<term>Dermatologic Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Inflammatory Agents</term>
<term>Antioxidants</term>
<term>Chalcones</term>
<term>Dermatologic Agents</term>
<term>Methotrexate</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Peau</term>
<term>Psoriasis</term>
<term>Épiderme</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Populus</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Chalcones</term>
<term>Populus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Epidermis</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Psoriasis</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Épiderme</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigène KI-67</term>
<term>Protéines membranaires</term>
<term>Précurseurs de protéines</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Epidermis</term>
<term>Psoriasis</term>
<term>Skin</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Chalcones</term>
<term>Produits dermatologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Psoriasis</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anti-inflammatoires</term>
<term>Antioxydants</term>
<term>Chalcones</term>
<term>Méthotrexate</term>
<term>Produits dermatologiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Topical</term>
<term>Adolescent</term>
<term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Inhibitory Concentration 50</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Quality of Life</term>
<term>Tissue Engineering</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Administration par voie topique</term>
<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Concentration inhibitrice 50</term>
<term>Femelle</term>
<term>Humains</term>
<term>Ingénierie tissulaire</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Qualité de vie</term>
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<front><div type="abstract" xml:lang="en">Psoriasis is a skin disorder characterized by epidermal hyperplasia, hyperkeratosis, and inflammation. The treatments currently available on the market only improve patients' quality of life and are associated with undesirable side effects. Thus, research leading to the development of new, effective, and safer therapeutic agents is still relevant. <i>Populus balsamifera</i>
 L. buds were used traditionally by Native Americans to treat various skin pathologies such as eczema and psoriasis. In this study, the antipsoriatic activities of dihydrochalcone derivatives from <i>Populus balsamifera</i>
 L. buds, known as balsacones, were investigated. The experiments were performed in vitro using a psoriatic skin substitute model. Also, anti-inflammatory and antioxidant activities were investigated. The tested balsacones showed promising antipsoriatic properties by slowing down cell growth and by regulating the expression of involucrin, loricrin, and Ki67 better than methotrexate in psoriatic substitutes. All five tested compounds could be an effective topical treatment for psoriasis, with promising anti-inflammatory and antioxidant actions that may contribute to clinical improvement in patients with psoriasis.</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>05</Month>
<Day>18</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>05</Month>
<Day>18</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1422-0067</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>21</Volume>
<Issue>1</Issue>
<PubDate><Year>2019</Year>
<Month>Dec</Month>
<Day>30</Day>
</PubDate>
</JournalIssue>
<Title>International journal of molecular sciences</Title>
<ISOAbbreviation>Int J Mol Sci</ISOAbbreviation>
</Journal>
<ArticleTitle>Dihydrochalcone Derivatives from <i>Populus balsamifera</i>
 L. Buds for the Treatment of Psoriasis.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">E256</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.3390/ijms21010256</ELocationID>
<Abstract><AbstractText>Psoriasis is a skin disorder characterized by epidermal hyperplasia, hyperkeratosis, and inflammation. The treatments currently available on the market only improve patients' quality of life and are associated with undesirable side effects. Thus, research leading to the development of new, effective, and safer therapeutic agents is still relevant. <i>Populus balsamifera</i>
 L. buds were used traditionally by Native Americans to treat various skin pathologies such as eczema and psoriasis. In this study, the antipsoriatic activities of dihydrochalcone derivatives from <i>Populus balsamifera</i>
 L. buds, known as balsacones, were investigated. The experiments were performed in vitro using a psoriatic skin substitute model. Also, anti-inflammatory and antioxidant activities were investigated. The tested balsacones showed promising antipsoriatic properties by slowing down cell growth and by regulating the expression of involucrin, loricrin, and Ki67 better than methotrexate in psoriatic substitutes. All five tested compounds could be an effective topical treatment for psoriasis, with promising anti-inflammatory and antioxidant actions that may contribute to clinical improvement in patients with psoriasis.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bélanger</LastName>
<ForeName>Audrey</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC GIJ 1Z4, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculté de Pharmacie, Université Laval, Québec, QC G1V 0A6, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC G7H 2B1, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Grenier</LastName>
<ForeName>Alexe</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC GIJ 1Z4, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculté de Pharmacie, Université Laval, Québec, QC G1V 0A6, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Simard</LastName>
<ForeName>François</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC G7H 2B1, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gendreau</LastName>
<ForeName>Isabelle</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC GIJ 1Z4, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculté de Pharmacie, Université Laval, Québec, QC G1V 0A6, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pichette</LastName>
<ForeName>André</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC G7H 2B1, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Legault</LastName>
<ForeName>Jean</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, QC G7H 2B1, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pouliot</LastName>
<ForeName>Roxane</ForeName>
<Initials>R</Initials>
<Identifier Source="ORCID">0000-0002-2423-9599</Identifier>
<AffiliationInfo><Affiliation>Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC GIJ 1Z4, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculté de Pharmacie, Université Laval, Québec, QC G1V 0A6, Canada.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>MOP-311262</GrantID>
<Acronym>CAPMC</Acronym>
<Agency> CIHR</Agency>
<Country>Canada</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>12</Month>
<Day>30</Day>
</ArticleDate>
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<MedlineJournalInfo><Country>Switzerland</Country>
<MedlineTA>Int J Mol Sci</MedlineTA>
<NlmUniqueID>101092791</NlmUniqueID>
<ISSNLinking>1422-0067</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000287" MajorTopicYN="N">Administration, Topical</DescriptorName>
</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D020128" MajorTopicYN="N">Inhibitory Concentration 50</DescriptorName>
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<MeshHeading><DescriptorName UI="D019394" MajorTopicYN="N">Ki-67 Antigen</DescriptorName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName>
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<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011788" MajorTopicYN="N">Quality of Life</DescriptorName>
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<MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName>
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<MeshHeading><DescriptorName UI="D023822" MajorTopicYN="N">Tissue Engineering</DescriptorName>
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<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">balsacone</Keyword>
<Keyword MajorTopicYN="N">dihydrochalcone</Keyword>
<Keyword MajorTopicYN="N">in vitro study</Keyword>
<Keyword MajorTopicYN="N">natural products</Keyword>
<Keyword MajorTopicYN="N">psoriasis</Keyword>
<Keyword MajorTopicYN="N">skin substitute</Keyword>
<Keyword MajorTopicYN="N">tissue engineering</Keyword>
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<ReferenceList><Reference><Citation>Mediators Inflamm. 2006;2006(3):16043</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16951486</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Dermatol Sci. 1990 Nov;1(6):441-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2288899</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Burns. 1993 Apr;19(2):99-104</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8471157</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Tissue Eng Part A. 2011 Jul;17(13-14):1859-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21417679</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Dermatol. 2001 Mar;40(3):223-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11422532</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Invest Dermatol. 1995 Mar;104(3):391-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7861008</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Mol Cell Biol. 2005 Apr;6(4):328-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15803139</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Immunol. 2014;32:227-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24655295</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Struct Biol. 1990 Jul-Sep;104(1-3):150-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2088443</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Nat Prod. 2015 May 22;78(5):1147-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25927817</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Protoc. 2006;1(3):1112-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17406391</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Sci. 2001 Sep;114(Pt 17):3069-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11590230</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Invest Dermatol. 1998 Sep;111(3):517-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9740250</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Tissue Eng Regen Med. 2015 Jul;9(7):789-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23281213</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Biol Med. 2009 Oct 1;47(7):891-905</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19577640</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Dermatol. 2012 Jan;166(1):204-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21790517</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Mol Sci. 2019 May 24;20(10):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31137673</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Dermatol. 2004 Jul;151(1):3-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15270867</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2009 Jul 30;361(5):496-509</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19641206</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Mol Sci. 2019 Apr 03;20(7):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30987186</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Res. 2016 Jun;50(6):585-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27098416</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Recent Pat Inflamm Allergy Drug Discov. 2012 Jan;6(1):3-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22022925</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Invest Dermatol. 2006 Dec;126(12):2565-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17108903</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Ethnobiol Ethnomed. 2012 Jan 30;8:7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22289509</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Dermatol Res. 2012 Aug;304(6):451-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22421888</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem. 2016 Sep 15;24(18):4188-4198</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27436809</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Food. 2010 Apr;13(2):460-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20132041</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Indian J Clin Biochem. 2010 Oct;25(4):388-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21966111</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>In Vitro Cell Dev Biol Anim. 1995 Jun;31(6):432-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8589886</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Acad Dermatol. 2006 Mar;54(3 Suppl 2):S67-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16488332</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Sci. 2009 May 1;122(Pt 9):1285-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19386895</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Dermatol. 1996 Apr;134(4):643-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8733364</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Phytochemistry. 2014 Apr;100:141-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24485585</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Ethnopharmacol. 2014;151(1):265-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24189030</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Dermatol Res. 1998 Jan-Feb;290(1-2):3-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9522994</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Dermatol Sci. 2009 Jan;53(1):19-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18783923</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2007 Feb 22;445(7130):866-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17314973</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Eur Acad Dermatol Venereol. 2001 Jan;15(1):16-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11451313</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Microbiol. 2019 Oct 15;10:2341</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31681206</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Actas Dermosifiliogr. 2016 Apr;107(3):194-206</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26614486</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Biotechnol. 2002 Dec;20(12):522-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12443874</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Dermatol. 2012 Sep;21(9):643-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22507538</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Biochem Biophys. 2013 Jul;66(3):523-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23283814</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Discov Today. 2008 Oct;13(19-20):894-901</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18691670</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Res Rev. 2015 Mar;35(2):306-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25171147</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Eur Acad Dermatol Venereol. 2012 Jul;26(7):833-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21749467</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Dermatol. 2000 Aug;10(6):429-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10980462</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Psoriasis (Auckl). 2016 Feb 22;6:7-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29387591</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
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Dihydrochalcone Derivatives from Populus balsamifera L. Buds for the Treatment of Psoriasis.

Dihydrochalcone Derivatives from Populus balsamifera L. Buds for the Treatment of Psoriasis.

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